史鵬

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教育背景

2002-2007    美國德克薩斯大學圣安東尼奧醫學中心(University of Texas Health Science Center at San Antonio)  博士  生理專業

1996-2001    泰山醫學院  學士  臨床醫學

科研經歷

2016/04-至今   浙江大學轉化醫學研究院 浙江大學第二附屬醫院   研究員

2012/08-2016/04美國西達賽奈醫學中心(Cedars Sinai Medical Center)    助理教授

2011/07-2012/07美國佛羅里達大學(University of Florida)          助理教授

2007/12-2011/06美國佛羅里達大學(University of Florida)          博士后

研究興趣與方向

1. 小膠質細胞(Microglia)介導的神經炎癥對心血管的調控機制

2. Microglia活性狀態的調控機制;以及其對自主神經活性的調節作用

3. Microglia在神經退行性病變中的作用機制

榮譽及獎勵

2009  American Heart Association Postdoctoral Fellowship Award

2011  Physiological Genomics Group/Featured Topic Travel Award

2011  American Heart Association Scientist Development Grant Award

2011  American Heart Association Annual High Blood Pressure Research Conference New Investigator Award

2012  American Physiological Society/Neural Control and Autonomic Regulation Section Postdoctoral and Early Career Research Recognition Award

2018  International Society of Hypertension Travel Award

學術組織任職

International Representative of American Physiological Society Neural Control and Autonomic Regulation Section                                                                     2016-

擔任雜志編輯

•  Cellular and Molecular Neurobiology

應邀審稿

•  Hypertension

•  Experimental Physiology

•  Vascular Pharmacology

•  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

•  International Journal of Hypertension

•  Journal of Hypertension

•  British Journal of Pharmacology

•  Journal of Cardiovascular Pharmacology and Therapeutics

•  Journal of Neurology & Neurophysiology

•  PLOS ONE

•  Cytokine

發表文章

編書:

1. Guingab, J.D., Kobeissy, F.H., Ratliff, M., Shi, P, Zhang, Z., Wang, K.K.W. Neurogenomic and neuroproteomic approaches to studying neural injury in "essentials of spinal cord injury."(Eds.. Fehlings,. Vaccaro,. Boakye,. Rossignol,. Ditunno, and. Burns), 2010. Thieme Publishers.

綜述:

1. Koronyo-Hamaoui M, Shah K, Koronyo Y, Bernstein E, Giani JF, Janjulia T, Black KL, Shi P, Gonzalez-Villalobos RA, Fuchs S, Shen XZ, Bernstein KE. ACE overexpression in myelonibicytic cells: effect of a mouse model of Alzheimer’s disease. Curr Hypertension Rep. 2014 Jul; 16(7):444. PMID: 24792094.

2. Bernstein KE, Gonzalez-Villalobos RA, Giani JF, Shah K, Bernstein E, Janjulia T, Koronyo Y, Shi P, Koronyo-Hamaoui M, Fuchs S, Shen XZ. Angiotensin converting enzyme over expression in myelocytes enhances immune response. Biological Chemistry, 2014, March, PMID: 24633750.

3. Gonzalez-Villalobos RA, Shen XZ, Bernstein EA, Janjulia T, Taylor B, Giani JF, Blackwell W-LB, Shah KH, Taylor BL, Shi P, Fuchs S, Bernstein KE. Rediscovering ACE: Novel insights into the many roles of the angiotensin-converting enzyme. Mol. Medicine (Berlin), 2013 Oct; 91(10): 1143-1154. PMID: 23686164.

4. de Kloet AD, Krause EG, Shi P, Zubcevic J, Raizada MK and Sumners C. Neuroimmune communication in hypertension and obesity: A new therapeutic angle? Pharmacology & Therapeutics. 2013 Feb; 138(8):428-40. PMID: 23458610.

5.Shi P, Raizada MK, Sumners C. Brain cytokines as neuromodulators in cardiovascular control.Clin Exp Pharmacol Physiol. 2010 Feb; 37(2):e52-7. PMID: 19566837.

研究論文:

1. Li Y, Shen XZ, Li L, Zhao TV, Bernstein KE, Johnson AK, Lyden P, Fang J and Shi P. Brain transforming growth factor bresists hypertension via regulating microglial activation. Stroke. 2017 Sep;48(9):2557-2564.PMID: 28698257.

2. Liu M, Shi P and Sumners C. Direct anti-inflammatory effects of angiotensin-(1-7) on microglia. J Neurochem. 2016 Jan; 136(1):163-71. PMID: 26448556.

3. Shah KH, Shi P*, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE and Shen XZ. Myeloid suppressor cells accumulate and regulate blood pressure in hypertension. Circ. Res. 2015, August; 117(10):858-69. (Editorial: Circ Res. 2015; 117(10):830-1) PMID: 26294657.* co-first author.

4. Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P and Shi P. Microglia participate in neurogenic regulation of hypertension. Hypertension. 2015, April; 66(2):309-16. (Editorial: Hypertension. 2015; 66(2):256-6) PMID: 26056339.

5. , Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK and Sumners C. Direct pro-inflammtory effects of prorenin on microglia. PlosOne. 2014, Oct; 10;9(10):e92937. doi: 10.1371 PMID: 25302502.Shi P

6. Shan Z, Zubcevic J, Shi P, Jun JY, Dong Y, Murca TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C and Raizada MK. Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension. 2013, June; 61(6):1328-33. PMID: 23547238.

7. Jiang N, Shi P, Desland F, Kitchen-Pareja MC and Sumners C. Interleukin-10 inhibits angiotensin II-induced decreases in neuronal potassium current. Am J Physiol Cell Physiol. 2013, April; 304(8):C801-7. PMID: 23426971.

8. . PMID: 23319541.Zubcevic J, Jun JY, Lamont G, Murça TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, Raizada MK, Shan Z. Nucleus of the solitary tract (Pro)renin receptor-mediated antihypertensive effect involved nuclear factor-κB-cytokine signaling in the spontaneously hypertensive rat. Hypertension. 2013, March; 61(3):622-7

9. Hypertension. 2010 Nov;56(5):956-63. PMID: 20937969.Colombari E, Colombari DS, Li H, Shi P, Dong Y, Jiang N, Raizada MK, Sumners C, Murphy D, Paton JF.

10. Amino Acids. 2011 Apr;40(4):1151-8. PMID: 20839013.Cao W, Glushakov A, Shah HP, Mecca AP, Sumners C, Shi P, Seubert CN, Martynyuk AE.

11. Circ Res. 2010 Oct;107(7):934-8. PMID: 20689062. *co-first author.Shan Z*, Shi P*, Cuadra AE, Dong Y, Lamont GJ, Li Q, Seth DM, Navar LG, Katovich MJ, Sumners C, Raizada MK.

12. P, Diez-Freire C, Jun JY, Qi Y, Katovich MJ, Li Q, Sriramula S, Francis J, Sumners C, Raizada MK. Hypertension. 2010 Aug;56(2):297-303. PMID: 20547972.Shi

13. Br J Pharmacol. 2009 Dec;158(8):2005-13. PMID:20050189.Cao W, Shah HP, Glushakov AV, Mecca AP, Shi P, Sumners C, Seubert CN, Martynyuk AE.

14. Hypertension. 2009 Oct;54(4):845-51. PMID: 19667250.Jiang N, Shi P, Li H, Lu S, Braseth L, Cuadra AE, Raizada MK, Sumners C.

15. FASEB J. 2008 Sep;22(9):3175-85. PMID: 18535252.Li H, Gao Y, Qi Y, Katovich MJ, Jiang N, Braseth LN, Scheuer DA, Shi P, Sumners C.

16. P, Martinez MA, Calderon AS, Chen Q, Cunningham JT, Toney GM. J Physiol. 2008 Nov 1;586(Pt 21):5231-45. PMID: 18755745.Shi

17. P, Stocker SD, Toney GM. Am J Physiol Regul Integr Comp Physiol. 2007 Dec; 293(6):R2279-89. PMID: 17898124.Shi



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