陸林宇

編輯:admin 時間:2018年11月12日 訪問次數:444

 
陸林宇
 
浙江大學轉化醫學研究院/附屬婦產科醫院,教授、博士生導師
 
受教育經歷
 
2003/01-2007/04,香港大學,生物化學系,博士
1999/09-2002/06,香港大學,生物化學系,學士
1998/09-1999/06,南京大學,生物化學系,本科(后轉學去香港大學)
 
研究工作經歷
 
2014/09-至今,浙江大學,醫學院,教授、博士生導師
2012/05-2014/08,美國密歇根大學,醫學院,研究員 (Research Investigator)
2007/05-2012/04,美國密歇根大學,醫學院,博士后 (Research Fellow)
2002/09-2002/12,香港大學,生物化學系,研究助理 (Research Assistant)
 
主要研究方向
 
DNA損傷修復與精子發生、DNA損傷修復與婦科腫瘤
 
主持或參加科研項目及人才計劃項目情況
1. 國家自然科學基金面上項目,BRCA1在男性精母細胞減數分裂中的作用,2015-2018,主持
2. 浙江省自然科學基金杰出青年項目,蛋白質泛素化在男性精母細胞減數分裂中的調控,2015-2018,主持
3. 國家重點研發計劃,人類配子發生、成熟障礙與胚胎停育的分子機制,2016-2020    ,子課題負責人
 
代表性文章
 
 1.Liu Y, Zhang B, Meng X, Korn MJ, Parent JM, Lu LY*, Yu X*. (2017) UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures. Epigenetics, 12:551-560.
 
 2.Han D, Liang J, Lu Y, Xu L, Miao S, Lu LY, Song W, Wang L. (2016) Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway. PLoS One, 11:e0155476.
 
 3.Liu Y, Zhang B, Kuang H, Korakavi G, Lu LY*, Yu X*. (2016) Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.  Journal of Biological Chemistry, 291:13679-88.
 
 4.Lu LY*, Yu X*. (2015) CHFR is important for the survival of male premeiotic germ cells. Cell Cycle, 14:3454-60.
 
 5.Lu LY*, Yu X*. (2015) Double-strand break repair on sex chromosomes: challenges during male meiotic prophase. Cell Cycle, 14:516-525.
 
 6.Lu LY*, Kuang H, Korakavi, Yu X*. (2015) Topoisomerase II regulates the maintenance of DNA methylation. Journal of Biological Chemistry, 290: 851-860.
 
 7.Li M, Lu LY, Yang CY, Wang S, Yu X. (2013) The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response. Genes & Development, 27: 1752-68.
 
 8.Lu LY, Xiong Y, Kuang H, Korakavi, Yu X. (2013) Regulation of the DNA damage response on male meiotic sex chromosomes. Nature Communications, 4:2105.
 
 9.Lu S, Lu LY, Liu MF, Yuan QJ, Sham MH, Guan XY, Huang JD. (2011) Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood. Neurobiology of Disease, 45: 215-233.
 
 10.Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X. (2011) Chfr and RNF8 synergistically regulate ATM activation. Nature Structural & Molecular Biology,18: 761-768.
 
 11.Wu J, Lu LY, Yu, X. (2010) Role of BRCA1 in DNA damage response. Protein&Cell. 1, 117-123.
 
 12.Lu LY, Wu J, Ye L, Gavrilina GB, Saunders TL, Yu X. (2010) RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell, 18:371-384.
 
 13.Lu LY, Yu X. (2009) The balance of Polo-like kinase 1 in tumorigenesis. Cell Division, 4:4.
 
 14.Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. (2009) Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Molecular and Cellular Biology, 29:849-860.
 
 15.Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. (2008) Aurora a is essential for early embryonic development and tumor suppression. Journal of Biological Chemistry, 283:31785-31790.
 
 16.Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. (2008) Polo-like Kinase 1 is Essential for Early Embryonic Development and Tumor Suppression. Molecular and Cellular Biology, 28:6870-6876.
 
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