李學坤

編輯:admin 時間:2018年11月07日 訪問次數:492

李學坤,博士,教授
工作單位:浙江大學轉化醫學研究院           
地址:浙江省杭州市江干區凱旋路268號,浙江大學華家池校區中心大樓北樓440房間
電子郵箱xuekun_li@
教育經歷:
2000/09-2003/06  協和醫科大學    博士
研究經歷
2014/12 -      浙江大學醫學院/浙江大學兒童醫院,教授
2013/06-2014/11   浙江大學生命科學學院,教授
2012/05-2013/06   美國Emory大學人類遺傳學系,研究助理教授
2010/10- 2012/04   美國Emory大學人類遺傳學系,Instructor
2008/12- 2010/09   美國Emory大學人類遺傳學系,博士后
2006/12- 2008/11   美國新墨西哥州大學神經科學系,博士后
2004/05- 2006/11   美國Emory大學細胞生物學系,博士后
榮譽和獎勵:
2012 Autism Speaks獨立研究獎
2009 FRAXA 研究基金會博士后研究獎
2008 6屆國際干細胞年會(ISSCR)旅游獎,費城,美國
2008 Autism Speaks基金會博士后研究獎
 
主要研究方向:
1. 表觀遺傳學修飾對神經發生和成體神經干細胞功能的調控作用
2. 表觀遺傳學修飾在神經系統疾病中的作用
發表論文:
1.    1. Li X#, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, Pan F, Dai Q, Zhang W, Wu H, Shu Q, Qin Z, He C, Xu M, Jin P#. Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature Communications 8: 15903(2017). (# co-correspondence).
 
2.    2. Li L, Zang L, Zhang F, Chen J, Shen H, Shu L, Liang F, Feng C, Chen D, Tao H, Xu T, Li Z, Kang Y, Wu H, Tang L, Zhang P, Jin P#, Shu Q#Li X#.Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.Hum Mol Genet 26(13): 2398-2411(2017). (# co-correspondence).
 
3.    3. Li Y, Park C, Vellón L, Li X. iPSCs: From Bench to Clinical Bed. Stem Cells Int. 8367587(2016).
 
4.    4.Liqi Shu, Wenjia Sun, Liping Li, Zihui Xu, Li Lin, Pei Xie, Hui Shen, Luoxiu Huang, Qi Xu, Peng Jin, XuekunLi.Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease. BMC Genomics 17(1):381-391(2016).
 
5.    5.Zhang P, Zhang L, Zhu L, Chen F, Zhou S, Tian T, Zhang Y, Jiang X, Li X, Zhang C, Xu L, Huang F.The change tendency of PI3K/Akt pathway after spinal cord injury. Am J Transl Res 15;7(11):2223-3222(2015).
 
6.    6.
 
7.    7.Sun, W*., Zang, L*., Shu, Q., Li., X. From development to diseases: The role of 5hmC in brain. Genomics104:347-351 (2014).
 
8.    8.Sun, W., Guan, M., and Li, X. 5-hydroxymethylcytosine mediated DNA demethylation in stem cells and development. Stem cells and Dev 23:923-930 (2014).
 
9.    9.Xu, Z., Poidevin, M., Li, X., Li, Y., Shu, L., Nelson, DL., Li, H., Hales, CM., Gearing, M., Wingo, TS., Jin, P. Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration. Proc Natl Acad Sci USA 110:7778-7783 (2013).
 
10  10.Wang. T., Wu,H., Li, Y., Szulwach, KE., Lin, L., Li, X., Chen, I., Goldlust, I., Chamberlain, S., Ananiev, G., Mowrey, J., Han, J., Kim, M., Yoon,Y., Rudd, M., Song, C., He, C., Chang, Q., Warren, S., Jin, P. Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nature Cell biology 15:700-711(2013).
 
11  11. Hong,Y., Chan, CB., Kwon, IS., Li, X., Song, M., Lee, HP., Liu, X., Sompol, P.,  Jin, P., Lee, HG., Yu, SP., Ye, K. (2012) SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. J Neurosci 32:17262-12772.
 
12  12.Wang, T., Pan, Q., Lin L, Szulwach, KE., Song, CX., He, C., Wu, H., Warren, ST., Jin, P., Duan, R., Li, X. (2012) Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum, Hum Mol Genet21,5500-5510.
 
13  13.Yu, M., Hon, G., Szulwach, K., Song, C., Zhang, L., Kim, A., Li, X., Dai, Q., Park, B., Min, J., Jin, P., Ren, B., He, C. (2012) Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell149,1368-1380.
 
14  14.Xu,Z., Li, X. DNA Methylation in Neurodegenerative Disorders. Curr Tran Geriatr Gerontol1:199–205 (2012).
 
15  15.Szulwach, K.E*., Li, X*., Li, Y., Song, C.X., Wu, H., Dai, Q., Irier, H., He, C. and Jin, P. (2011) 5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging. Nature Neuroscience 14:1607-1616 (* equal contribution).
 
16  16.Szulwach, KE., Li, X, Li, Y., Song, CX., Han, JW., Kim, S., Namburi,S., Hermetz, K., Kim, JJ., Rudd, MK., Yoon, YS., Ren, B., He, C., Jin, P. (2011) Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet 7: e1002154.
 
17  17.Qurash,A., Li, X*., Jin, P*. (2011) Fragile X Mental Retardation Protein and Stem Cells. (* co-corresponding author; Robert B. Denman edited, Springer)
 
18  18.Song, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T., Jin, P., and He, C. (2011) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nature Biotechnology 29,68-72.
 
19  19.Li, X. and Jin, P. (2010) Roles of small regulatory RNAs in determining neuronal identity. Nature Reviews Neurosci 11:329-338.
 
20  20.Luo, Y., Shan, G., Guo, W., Smrt, R.D., Johnson, E., Li, X., Duan, R., Barkho, B.Z., Li, W., Jin, P., and Zhao, X. (2010) Fragile X mental retardation protein regulates adult neurogenesis. PLoS Genetics 6: e1000898.
 
21  21.Smrt, RS., Szulwach, KE., Pfeiffer, RL., Li, X., Guo, W., Pathania, M., Luo, Y., Wilson, MC., Bordey, A., Jin, P., and Zhao, X.(2010)MicroRNA miR-137 modulates neuronal maturation through translational regulation of Mind Bomb-1. Stem Cells 28:1060-1070.
 
22  22.Szulwach, KE*., Li, X*., Smrt, RS., Li, Y., Luo, Y., Lin, L., Santistevan, N., Li, W., Zhao X., and Jin, P. (2010) MeCP2-mediated crosstalk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biology 189:127-141(*equal contribution).
 
23  23.Li, X., and Jin, P.(2009) 
 
24  24.Barkho, B., Munoz., A., Li, X., Li, L., Cunningham, L., and Zhao, X. (2008) Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 mediate the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells 26: 3139-3149.
 
25  25. Li, X., Tang, X., Jablonska, B., Aguirre, A., Gallo, V., and Luskin, M. (2009) p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse. J Neurosci29:2902-2914.
 
26  26.Szulwach, K., Li, X., Zhao, X, Jin, P. (2009) Epigenetic Regulation of miRNA in Stem Cells. Current Perspective in miRNAs, (Springer).
 
27  27. Li, X., Barkho. BZ., Luo, Y., Smrt, RD., Santistevan, NJ., Liu, C., Kuwabara, T., Gage, FH., Zhao, X. (2008) Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem 283:27644-27652.
 
28  28.Allan, A., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K., Chen, D., Jin, P., Zhao, X. (2008) The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Hum Mol Genet 17:2047-2057.
 
29  29.Li, X., Zhao, X. (2008) Epigenetic Regulation of mammalian stem Cells. Stem Cells Dev 17:1043-1052.
 
30  30. Li, X., Barkho, BZ., Zhao, X. (2008) Neural stem cells and neurogenic niche in the adult brain. Stem Cell Research and Therapeutics edited by Shi Y and Clegg D. Springer   
 
31  31. Kong, X., Li, X., Cai, Z., Yang, N., Liu, Y., Shu, J., Pan, J., Zuo, P. (2008) Melatonin regulates viability and differentiation of rat midbrain neural stem cells. Cellular and Molecular Neurobiology 28:569-579.
 
32  32.Tang, X*., Falls, L*., Li, X., Lane, T., and Luskin, MB. (2007) Antigen-Retrieval Procedure for Bromodeoxyuridine Immunolabeling with Concurrent Labeling of Nuclear DNA and Antigens Damaged by HCl Pretreatment. J Neurosci 27:5837-5844.
 
33  33.Cui, X., Zuo, P., Zhang, Q., Li, X., Hu, Y., Long, J., Packer, L., Liu, J. (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-alpha-lipoic acid. J Neurosci Res83:1584-1590.
 
34  34.Zhang Q., Huang Y., Li, X., Cui X., Zuo P. and Li J. (2005) GM1 ganglioside prevented the decline of hippocampal neurogenesis associated with D-galactose. Neuroreport 16:1297-1301.
 
35  35.Zhang Q*., Li, X*., Cui X. and Zuo P. (2005) D-Galactose injured neurogenesis in the hippocampus of adult mice. Neurol Res 27: 552-556.
 
36  36.Li, X., and Zuo P. (2005) Effects of Aβ25-35 on neurogenesis in the adult mouse subventricular zone and dentate gyrus. Neurol Res 27: 218-222.
 
37  37.Li, X., Guo A. and Zuo P. (2003) Survival and differentiation of transplanted neural stem cell in the brain of MPTP-induced Parkinson’s disease model mouse. ACTA PHARMACOLOGICA SINICA 24:1192-1198.
 
基金資助:
“Ogt介導的O-GlcNAc糖基化修飾對成年小鼠神經干細胞和學習記憶的調控作用與機制研究
國家自然基金面上項目                                             2016.1-2019.12  
“5-羥甲基胞嘧啶對成體神經干細胞和神經發生的表觀遺傳學調控研究
人社部回國人員啟動基金(優秀類)                     2015.1-2015.12
 “聽覺微環路障礙形成的遺傳和分子機制
科技部“973”項目子課題(骨干)                               2014.1-2018.12
“5-羥甲基胞嘧啶對成體神經干細胞和神經發生的表觀遺傳學調控研究
國家自然基金面上項目                                         2014.1-2017.12         
“5-Hydroxymethylcytosine-Mediated Epigenetic Modulation in Autism Spectrum Disorders”
Autism Speaks Foundation                                        2012.1-2013.12
Roles: PI
“Small Molecule Screen using Fragile X Neural Stem Cells”  
Fragile X Research Foundation                                    2009.5-2011.4 
Roles: Postdoctoral Fellow
“MBD1 regulation of anxiety and autism”
Autism Speaks                                                              2008.1-2008.12
Roles: Postdoctoral Fellow
 

 

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