陸燕

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陸燕
浙江大學醫學院轉化醫學研究院及附屬婦產科醫院雙聘的海外高層次引進人才,教授、博導。回國前擔任美國威斯康星醫學院Tenure tracked助理教授。長期從事生物信息學及其在腫瘤等人類復雜疾病遺傳學方面的應用研究。目前已發表了60多篇SCI論文。
實驗室鏈接:http://bioinformatics.
教育背景:
1992-1996 安徽農業大學,農學,學士
1996-1999安徽農業大學,作物遺傳育種,碩士
1999-2003浙江大學,統計遺傳與生物信息學,博士
研究工作經歷:
2003-2004 Creighton 大學,醫學中心,博士后,Postdoctoral Researcher
2004-2007華盛頓大學(圣路易斯),外科系,博士后,Postdoctoral Researcher
2007-2008華盛頓大學(圣路易斯),外科系,研究員, Senior Scientist
2008-2010華盛頓大學(圣路易斯),外科系,研究助理教授, Research Assistant Professor
2010-2014威斯康星醫學院,助理教授,Tenure-tracked Assistant Professor
2014-至今浙江大學,轉化醫學研究院和附屬婦產科醫院,教授,Professor
2014-至今威斯康星醫學院,兼職教授,Adjunct Professor
專業社會活動:
Member, American Society of Human Genetics
Member, American Society of Cancer Research
Reviewer: Bioinformatics
Reviewer: Genetica
Reviewer: PLoS One
Reviewer:Osteoporosis International
Reviewer: Molecular Carcinogenesis
Reviewer: Physiology Genomics
Reviewer: Journal of Thoracic Oncology
Reviewer: Briefs of Bioinformatics
中國研究型醫院學會婦產科學專業委員會常務委員
主持科研項目:
研究方向:
主要包括:(1)發展高通量基因組和表觀基因組數據的分析平臺和(2)揭示婦科癌的發生、發展和轉移的分子機制。綜合試驗和生物信息學方法鑒定人類群體和動物模型中的基因功能。我們的研究最終目標是在婦科癌中發現新的診斷和預后的生物學標記及其藥物靶點。
研究論文:
1. Liu P, Zhu J, Lou X, Lu Y. A method for marker-assisted selection based on QTLs with epistatic effects. Genetica. 2003;119:75-86.
2. Long JR, Liu PY, Liu YJ, Lu Y, Xiong DH, Elze L, et al. APOE and TGF-beta1 genes are associated with obesity phenotypes. J Med Genet. 2003;40:918-24.
3. Liu P, Zhu J, Lu Y. Marker-assisted selection in segregating generations of self-fertilizing crops. TheorAppl Genet. 2004;109:370-6.
4. Liu PY, Lu Y, Long JR, Xu FH, Shen H, Recker RR, et al. Common variants at the PCOL2 and Sp1 binding sites of the COL1A1 gene and their interactive effect influence bone mineral density in Caucasians. J Med Genet. 2004;41:752-7.
5. Liu YJ, Rocha-Sanchez SM, Liu PY, Long JR, Lu Y, Elze L, et al. Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families. Physiol Genomics. 2004;17:101-6.
6. Long JR, Liu PY, Liu YJ, Lu Y, Shen H, Zhao LJ, et al. APOE haplotypes influence bone mineral density in Caucasian males but not females. Calcif Tissue Int. 2004;75:299-304.
7. Long JR, Liu PY, Lu Y, Xiong DH, Zhao LJ, Zhang YY, et al. Association between COL1A1 gene polymorphisms and bone size in Caucasians. Eur J Hum Genet. 2004;12:383-8.
8. Long JR, Zhao LJ, Liu PY, Lu Y, Dvornyk V, Shen H, et al. Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. BMC Genet. 2004;5:11.
9. Lu Y, Liu PY, Liu YJ, Xu FH, Deng HW. Quantifying the relationship between gene expressions and trait values in general pedigrees. Genetics. 2004;168:2395-405.
10. Zhao LJ, Liu PY, Long JR, Lu Y, Xu FH, Zhang YY, et al. Test of linkage and/or association between the estrogen receptor alpha gene with bone mineral density in Caucasian nuclear families. Bone. 2004;35:395-402.
11. Liu PY, Zhang YY, Lu Y, Long JR, Shen H, Zhao LJ, et al. A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases. J Med Genet. 2005;42:221-7.
12. Liu YJ, Liu PY, Long J, Lu Y, Elze L, Recker RR, et al. Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics. 2005;22:197-203.
13. Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe JM, Recker RR, et al. A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes.J Biol Chem. 2005;280:29011-6.
14. Long JR, Liu PY, Lu Y, Dvornyk V, Xiong DH, Zhao LJ, et al. Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass. Osteoporos Int. 2005;16:86-92.
15. Lu Y, Zhu J, Liu PY. A two-step strategy for detecting differential gene expression of cDNA microarray data.Curr Genet.2005;47:121-131.
16. Lu Y, Liu PY, Xiao P, Deng HW. Hotelling's T2 multivariate profiling for detecting differential expression in microarrays.Bioinformatics. 2005;21:3105-13.
17. Xiao P, Liu PY, Lu Y, Guo YF, Xiong DH, Li LH, et al. Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach. Hum Genet. 2005;117:340-8.
18. Zhang YY, Liu PY, Lu Y, Davies KM, Dvornyk V, Recker RR, et al. Race and sex differences and contribution of height: a study on bone size in healthy Caucasians and Chinese. Am J Hum Biol. 2005;17:568-75.
19. Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, et al. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat Genet. 2006;38:888-95.
20. Liu PY, Lu Y, Deng HW. Accurate haplotype inference for multiple linked single-nucleotide polymorphisms using sibshipdata.Genetics. 2006;174:499-509.
21. Liu PY, Zhu J, Lu Y. Impacts of QTL x environment interactions on genetic response to marker-assisted selection. Yi ChuanXueBao. 2006;33:63-71.
22. Lu Y, Lemon W, Liu PY, Yi Y, Morrison C, Yang P, et al. A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med. 2006;3:e467.
23. Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, et al. A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice.Cancer Res. 2006;66:1956-63.
24. Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, et al. Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. Mol Cancer Res. 2006;4:971-81.
25. Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, et al. Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets. Carcinogenesis. 2006;27:1420-31.
26. Zhang YY, Liu PY, Lu Y, Xiao P, Liu YJ, Long JR, et al. Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians. J Bone Miner Metab. 2006;24:36-41.
27. Liu P, Vikis H, Lu Y, Wang D, You M. Large-scale in silico mapping of complex quantitative traits in inbred mice. PLoS One. 2007;2:e651.
28. Lu Y, Yi Y, Liu P, Wen W, James M, Wang D, et al. Common human cancer genes discovered by integrated gene-expression analysis. PLoS One. 2007;2:e1149.
29. Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, et al. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst. 2008;100:1326-30.
30. James MA, Lu Y, Liu Y, Vikis HG, You M. RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. Cancer Res. 2009;69:2108-16.
31. Liu PY, Vikis H, James M, Lu Y, Wang DL, Liu HB, et al. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Cancer Res. 2009;69:6290-8.
32. You M, Wang D, Liu P, Vikis H, James M, Lu Y, et al. Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res. 2009;15:2666-74.
33. Liu P, Lu Y, Recker RR, Deng HW, Dvornyk V. ALOX12 gene is associated with the onset of natural menopause in white women. Menopause. 2010;17:152-6.
34. Liu P, Lu Y, Recker RR, Deng HW, Dvornyk V. Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women. Menopause. 2010;17:185-90.
35. Liu P, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, et al. Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer. Cancer Epidemiol Biomarkers Prev. 2010;19:517-24.
36. Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, et al. A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.Cancer Res. 2010;70:3128-35.
37. Lu Y, Liu P, James M, Vikis HG, Liu H, Wen W, et al. Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor. Oncogene. 2010;29:1041-9.
38. Lu Y, Liu P, Recker RR, Deng HW, Dvornyk V. TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. Menopause. 2010;17:1048-54.
39. Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, et al. Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. Mol Cancer Ther. 2010;9:3074-82.
40. Lu Y, Liu P, Wen W, Grubbs CJ, Townsend RR, Malone JP, et al. Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. Am J Translational Res. 2011;3:8-21.
41. Fu H, Zhang J, Pan J, Zhang Q, Lu Y, Wen W, Lubet RA, Szabo E, Chen R, Wang Y, Chen DR, You M. Chemoprevention of Lung Carcinogenesis bythe Combination of Aerosolized Budesonide andOral Pioglitazone in A/J Mice. MolCarcinog. 2011 Mar 3. doi: 10.1002/mc.20751.
42. Lubet RA, Lu Y, Bode AM, You M, Verney ZM, Steele VE, Townsend R, Juliana MM, Grubbs CJ.Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: dose dependency and modulation of biomarkers.Oncol Rep. 2011 25(5):1389-97.
43. Lu Y, Liu YZ, Liu PY, Dvornyk V, Deng HW. A bootstrap-based regression method for comprehensive discovery of differential gene expressions: An application to the osteoporosis study. Eur J Med Genet.2011 Jul 30.
44. LuY, Liu P, Van den BerghF, Zellmer V, James M, Wen W, Grubbs CJ, Lubet RA, and You M. Modulation of Gene Expression and Cell Cycle Signaling Pathways in Iressa-treated Urinary Bladder Cancer in Rats. Cancer Prevention Research.2012 Feb;5(2):248-59.
45. Liu P, Lu Y, Liu H, Wen W, Jia D, Wang Y, You M. Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice.Mol Cancer Res. 2012 Jan;10(1):66-74. Epub 2011 Nov 29.
46. Lu Y, Govindan R, Wang L, Liu P, Goodgame B, Wen W, Sezhiyan A, Li Y, Hua X, Wang Y, Yang P, You M. MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer. Carcinogenesis. 2012 May;33(5):1046-54.
47. Lu Y, Wang L, Liu P, Yang P, You M.Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients. PLoS One. 2012;7(1):e30880..
48. Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X,  Ding F, Lu Y, et al. Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing.Carcinogenesis.2012;33(7):1270-6
49. Vedell P, Lu Y, Grubbs C, Yin Y, Jiang H, Bland K, Muccio DD, Cvetkovic D, You M, Lubet R. Effects on Gene Expression in Rat Liver after Administration of RXR Agonists:
UAB30, 4-Methyl-UAB30, and Targretin (Bexarotene).MolPharmacol2013;83(3):698-708
50. Hua X, Xu H, Yang Y, Zhu J, Liu P*,Lu Y*.DrGaP: A Powerful Tool for Identifying Driver Genes and Pathways in Cancer Sequencing Studies.Am J Hum Genet. 2013;93(3):439-51 (co-corresponding author).
51. Lu Y, You M, Ghazoui Z, Liu P, Vedell PT, Wen W, Bode AM, Grubbs CJ, Lubet RA. Concordant Effects of Aromatase Inhibitors on Gene Expression in ER+ Rat and Human Mammary Cancers and Modulation of the Proteins Coded by these Genes.CancerPrev Res (Phila).2013 Sep 25.[Epub ahead of print].
52. Nicastro HL, Grubbs CJ, Juliana MM, Bode AM, Kim MS, Lu Y, You M, Milne G, Boring D, Steele VE, LubetRA.Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model.CancerPrev Res (Phila).2013 Dec 17. [Epub ahead of print]
53. Chen E, Liu P, Lu Y*. Cancer genomics: new software tools making sequencing more accessible. Personalized Medicine.2014, 2.
54. Huang X, Yuan T, Liang M, Du M, Xia S, DittmarR, Wang D, See W, Costello BA, QuevedoF, Tan W,NandyD, Bevan GH, LongenbachS, Sun Z, Lu Y,Wang T, Thibodeaum SN, Boardman L, Kohli M, Wang L. Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistantProstate Cancer. EurUrol (2014),
55. Du M, Yuan T, Schilter KF, Dittmar RL, Mackinnon A, Huang X, Tschannen M, Worthey E, Jacob H, Xia S, Gao J, Tillmans L, Lu Y, Liu P, Thibodeau SN, Liang Wang. Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.Human Molecular Genetics (2014).
56. Chu C, Fang Z, Hua X, Yang Y, Chen E, Cowley A, Liang M, Liu P*, Lu Y*. deGPS is a powerful tool for detecting differential expression in RNA-sequencing studies. BMCGenomics. 2015http://www.biomedcentral.com/1471-2164/16/455 (co-corresponding author)
57. Li L, Chen E, Yang C, Zhu J, Jayaraman P, De Pons J, Kaczorowski CC, Jacob HJ, Greene AS, Hodges MR, Cowley AW Jr, Liang M, Xu H, Liu P*, Lu Y*. Improved rat genome gene prediction by integration of ESTs with RNA-Seq information. Bioinformatics. 2015 Jan 1;31(1):25-32. doi: 10.1093/bioinformatics/btu608. (co-corresponding author).
58. Olasz EB, Seline LN, Schock AM, Duncan NE, Lopez A, Lazar J, Flister MJ, Lu Y, Liu P, Sokumbi O, Harwood CA, Proby CM, Neuburg M, Lazarova Z.MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma.PLoS One. 2015 May 4;10(5):e0125412.
59. Xu H, Ma Y, Zhang Y, Pan Z, Lu Y, Liu P, Lu B.Identification of Cathepsin K in the Peritoneal Metastasis of Ovarian Carcinoma Using In-silico, Gene Expression Analysis.J Cancer. 2016 Mar 26;7(6):722-9.
60. Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K, Thomas JP, Myers CR, Stoner G, Chen G.p38γ MAPK is required for inflammation-associated colon tumorigenesis.Oncogene. 2016 Feb 25;35(8):1039-48.
61. Dong A, Lu Y, Lu B.Genomic/Epigenomic Alterations in Ovarian Carcinoma: Translational Insight into Clinical Practice.J Cancer. 2016 Jul 5;7(11):1441-51.
62. Ma Y, Lu Y, Lu B.MicroRNA and Long Non-Coding RNA in Ovarian Carcinoma: Translational Insights and Potential Clinical Applications.Cancer Invest. 2016 Oct 20;34(9):465-476.
63. Liu P, Iden M, Fye S, Huang YW, Hopp E, Chu C, Lu Y, Rader JS. Targeted, deep sequencing reveals full methylation profiles of multiple HPV types andpotential biomarkers for cervical cancer progression. Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):642-650.
64. ZhangH#, Lu Y#, Chen E#, Li X, LvB , VikisHG, Liu P*,XRN2 promotes EMT and metastasis through regulatingmaturation of miR-10a. Oncogene. 2017 Jul 6; 36(27):3925-3933.。
65. Yu Y, Lu B, Lu W, Li S, Li X, Wang X, Wan X, Chen Y, Feng S, Jia Y, Yang R, Tang F, Li X, Zhang S, Wang X, Wei H, Peng Z, Lu L, Zhong H, Zhao L, Huang Z, Lin L, Shen W, Lu Y, Cao Z, Zou J, Ma Y, Chen X, Tian Q, Lu S, Liu P*, Ma D*, Xie X*, Cheng X*. Whole-exome sequencing reveals genetic variants in ERC1 and KCNG4 in complete hydatidiform moles from Chinese Han women. Oncotarget. 2017 Sep 8;8(43):75264-75271.
66. Xiwei Sun#, Yi Han#, Liyuan Zhou, Enguo Chen, BingjianLv, Yong Liu, Xiaoqing Pan, Allen W. Cowley, Jr. , Mingyu Liang, Qingbiao Wu, Yan Lu*, Pengyuan Liu*. A comprehensive evaluation of alignment software for reduced representation bisulfite sequencing data. Bioinformatics. 2018 Mar 22. doi: 10.1093/bioinformatics/bty174.
BOOKS, CHAPTERS & REVIEWS
Lu Y. Liu P, Deng H.W. Multivariate analysis of microarray data using Hotelling's T2 test. InMedical Biostatistics for Complex Diseases, edited by F. Emmert-Streib and M. Dehmer.Wiley-VCH; 2010. p. 113-30.
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