謝安勇

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謝安勇 簡歷

浙江大學轉化醫學研究院,浙江大學醫學院附屬邵逸夫醫院,教授、博導
 
研究方向
1. 1. 腫瘤基因組不穩定性及腫瘤靶向藥物研發
2. 2. CRISPR基因編輯技術改良與應用
3. 3. 肝癌發生機制及臨床應用
 
教育經歷(從大學本科開始,按時間倒排序)
1996/8 - 2002/7,美國University of Missouri at Columbia,生物化學,博士,
 導師:William Folk
1999/9 - 2001/7,美國University of Missouri at Columbia,工商管理,碩士
1992/9 - 1995/7,中國科學院植物研究所,分子生物學,碩士,導師:宋艷茹
   1988/9 - 1992/7,北京大學,植物生理學,學士
 
研究工作經歷(按時間倒排序)
2014/2 - 至今,浙江大學轉化醫學研究院及附屬邵逸夫醫院,研究員
2008/4 - 2014/2,哈佛醫學院,講師
2002/09–2008/04,哈佛醫學院/貝斯以色列女執事醫療中心,博士后,導師:Ralph Scully
1995/7 - 2002/8,中國科學院植物研究所,植物分子生物學,助理研究員
 
獎勵
1.
2.  1. Margaret Cheng Scholarship,University of Missouri-Columbia,1996年
3.  2. 中國科學院院長獎學金優秀獎,1995年
 
專業協會成員
1.    浙江省醫學會腫瘤學分會腫瘤精準醫學學組副組長(2015-至今)
2.    中國細胞生物學會會員(2014-至今)
3.    Dana Farber/Harvard Cancer Center Breast Cancer Research Program成員  (2012-2014)
4.    International Association for Biological and Medical Research (IABMR)成員(2007)
5.    American Association for Cancer Research (AACR) 成員(2007)
6.    Society for Experimental Biology and Medicine (SEBM) 成員(2006)
 
主持科研項目情況
2017-2020,Z17C060003,浙江省自然科學基金重點項目,《DNA 雙鏈斷裂修復因子ATM 在CRISPR 基因編輯調節中的作用機制研究》,¥40萬,主持
2017-2020,31671385,國家自然科學基金面上項目,《CRISPR基因編輯技術的DNA雙鏈斷裂修復機制研究》,¥74.4萬,主持
2016/7-2019/6,81661128008,2016年度國家自然科學基金委員會(NSFC)與加拿大魁北克研究基金會醫學部(FRQS)癌癥合作研究項目,《靶向DNA損傷應答與修復的癌癥個體化治療研究》,¥300萬,參與
2016-2018,2015C03047,浙江省重點研發計劃,《肝癌個性化治療模式研究》,¥100萬,主持
2015-2018,81472755,國家自然科學基金面上項目,《抗癌藥物PARP抑制劑獲得性耐藥的進化研究》,¥72萬,主持
2015-2017, 浙江大學轉化醫學研究院種子基金,《肝癌循環腫瘤DNA富集、檢測微流控芯片研發》,¥20萬,主持
2015-2017,2015-ZJKL-ND-001,浙江省新生兒疾病診治重點實驗室開放基金,《小兒毛細血管擴張性共濟失調癥神經元退化的分子機制研究》,¥5萬,主持
2014-2016,浙江大學及浙江大學醫學院附屬邵逸夫醫院啟動經費,¥200萬,主持
 
評審人
2017,科技創新領軍人才和科技創業領軍人才評審人
2015-至今,國家自然科學基金評審人和浙江省自然科學基金評審人
2008-至今,國際頂級學術雜志Nature Medicine, Nature Cell Biology, Nature Communications, PLOS Genetics, Nucleic Acids Research,Oncogene,Acta Biochim Biophys Sin,Mutation Research,Molecular and Cellular Biology,Scientific Reports論文評審人                     
 
專利申請
   謝安勇,郭濤,馮依力:一種CRISPR/Cas9工作效率快速測試系統及其應用;
   專利申請號:201610073847.1
 
論著(期刊論文;*: 通訊作者
1.   1. Xie X, Hu H, Tong X, Li L, Liu X, Chen M, Yuan H, Xie X, Li Q, Zhang Y, Ouyang H, Wei M, Huang J, Liu P, Gan W, Liu Y, Xie A, Kuai X, Chirn GW, Zhou H, Zeng R, Hu R, Qin J, Meng FL, Wei W, Ji H, Gao D*. The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nat Cell Biol 2018; 20: 320-331.
2.    2.  Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, Liu T, Huang J*. BRCA2 antagonizes 53BP1/RIF1/Artemis-dependent classical and alternative nonhomologous end-joining to prevent gross genomic instability. Nat Commun2017; 8: 1470. (影響因子: 11.470)
3.    3. Feng Y-L, Xiang J-F, Liu S-C, Guo T, Yan G-F, Feng Y, Kong N, Li H-D, Huang Y, Lin H,
Cai X-J*, Xie A-Y*. H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Res, 2017; 45: 10614-10633. (影響因子: 10.162)
4.   4.   Guirouilh-Barbat J, Gelot C, Xie A, Dardillac E, Scully R, Lopez BS*. 53BP1 protects against ctip-dependent capture of ectopic chromosomal sequences at the junction of distant double strand breaks. PLOS Genet, 2016; 12:e1006230. (影響因子: 6.668)
5.   5.   Tang J-C, Feng Y-L, Guo T, Xie A-Y*, Cai X-J*. Circulating tumor DNA in hepatocellular carcinoma: trends and challenges. Cell Biosci, 2016; 6:32. (影響因子: 2.089)
6.   6.    Feng Y-LXiang J-FKong NCai X-J*Xie A-Y*. Buried territories: heterochromatic response to DNA double strand breaks.Acta Biochim Biophys Sin, 2016; 48:594-602 (受邀綜述) (影響因子: 2.089)
7.   7.  Chen J, Ji T, Zhao J, Li G, Zhang J, Jin R, Liu J, Liu X, Liang X, Huang D, Xie A, Lin H*, Cang Y*, Cai X*. Sorafenib-resistant hepatocellular carcinoma stratified by phosphorylated ERK activates PD-1 immune checkpoint. Oncotarget, 2016. 7:41274-41284. (影響因子: 5.008)
8.   8.    Liu J, Li J, Fu W, Tang J, Feng X, Chen J, Liang Y, Jin R, Xie A, Cai X*. Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation. Drug Des Devel Ther2015; 9:5655-67. (影響因子: 3.028)
9.   9.   Liu X-S, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R*, Lunardi A*, Pandolfi PP*. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun, 2015; 6:8325. (影響因子: 11.470)
     10. Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W*. Akt-mediated phosphorylation of XLF impairs non-homologous end joining DNA repair. Mol Cell, 201557: 648–661. (影響因子: 14.018)
      11. Tang JC, Xie AY, Cai XJ. Diverse functions of fibulin-5 in tumor. Mol Biol, 2014, 48: 761-766
      12. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM*. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov, 2014; 4:1430-1447. (影響因子: 19.453) 
      13. Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R*. BRCA1 and CtIP suppress long tract gene conversion between sister chromatids. Nat Commun, 20134:2404. (影響因子: 11.470)
      14. Rass E, Chandramouly G, Zha S, Alt FW, Xie A*. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem, 2013288:7086-7095. (影響因子: 4.573)
      15. Scully R* and Xie A. Double strand break repair functions of histone H2AX. Mutat Res2013750: 5-14 (peer reviewed). (影響因子: 3.680)
      16. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R*. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. PLoS One, 20127:e49211. (影響因子: 3.234)
      17. Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC*. Nek4 regulates entry into replicative senescence and the response to DNA-damage in human fibroblasts. Mol Cell Biol, 201232: 3963-3977. (影響因子: 4.777)
      18. Hu Y, Scully R, Sobhian B, Xie A, Shestokova E, Livingston DM*. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev 2011; 25:685-700. (影響因子: 10.798)
      19. Xie A, Odate S, Chandramouly G, Scully R*. H2AX post-translational modifications in the ionizing radiation response and homologous recombination. Cell Cycle 2010; 9: 3602-3610. (Highlighted in News and Views in Cell Cycle, 2010; 9:3845). (影響因子: 4.565)
      20. Xie A*, Kwok A, Scully R*. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 2009; 16:814-818 (*, Co-corresponding authorship). (Highlighted in News and Views in Nat Struct Mol Biol 2009; 16:798-800). (影響因子: 13.309)
      21. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R*. Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair. Mol Cell 2007; 28:1045-1057. (Evaluated and recommended by Faculty of 1000). (影響因子: 14.018)
      22. Xie A and Scully R*. Hijacking the DNA damage response to enhance viral replication: γ-Herpesvirus 68 orf36 phosphorylates histone H2AX. Mol Cell 2007; 27:178-179. (影響因子: 14.018)
      23. Nagaraju G, Odate S, Xie A, Scully R. Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C. Mol Cell Biol 2006; 26:8075-8086. (影響因子: 4.777)
      24. Scully R* and Xie A. In my end is my beginning: control of end resection and DSBR pathway “choice” by cyclin-dependent kinases. Oncogene 2005; 24:2871-2876. (影響因子: 8.459)
      25. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R*. Control of sister chromatid recombination by histone H2AX. Mol Cell 2004; 16:1017-1025. (影響因子: 14.018)
      26. Scully R* and Xie A. BRCA1 and BRCA2 in breast cancer predisposition and recombination control. J Mammary Gland Biol Neoplasia 2004; 9:237-246. (影響因子: 4.526)
      27. Scully R*, Xie A, Nagaraju G.Molecular functions of BRCA1 in the DNA damage response. Cancer Biol Ther 2004; 3:521-527. (影響因子: 3.072)
      28. Xie A-Y and Folk WR*. Inhibition of polyomavirus ori-dependent DNA replication by mSin3B. J Virol 2002; 76:11809-11818. (影響因子: 4.439)
      29. Xie A-Y, Bermudez VP, Folk WR*. Stimulation of DNA replication from the polyomavirus origin by PCAF and GCN5 acetyltransferases: Acetylation of large T antigen. Mol Cell Biol 2002; 22:7907-7918. (影響因子: 4.777)
      30. Berjanskii MV, Riley MI, Xie A, Semenchenko V, Folk WR, Van Doren, SR*. NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens.  J Biol Chem 2000; 275:36094-36103. (影響因子: 4.573)
      31. Yong W-D, Liang T-B, Xie A-Y, Li C, Song Y-R*. PhbB, phbC gene expression in E. coli and their transformation and identification in potato. Acta Botanica Sinica 1998; 40:615-621.
      32. Xie A-Y, Cui X-J, Song Y-R*. Cloning and sequencing of Alcaligenes eutrophus H16 phbB and phbC genes and construction of their plant expression vectors. Acta Botanica Sinic   a 1995; 37:581-588.
      33. Song Y-R* and Xie A-Y. Biosynthesis of ethylene and molecular regulation of fruit maturation. Acta Botanica Sinica 1994; 36 (SUPPL.):1-13.
      34. Xie A-Y and Song Y-R*. Applications of biotechnology in producing biodegradable plastic PHB. Chinese Bulletin of Botany 1994; 11:21-25. 













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