趙永超

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趙永超,博士,浙江大學轉化醫學研究院研究員,浙江大學醫學院附屬第一醫院衛生部多器官聯合移植研究重點實驗室研究員、博士生導師。長期致力于腫瘤發生的分子機制研究,在腫瘤細胞信號調控、腫瘤發生和發展的分子機理以及抗腫瘤藥物作用機制等方面積累了豐富的理論和研究經驗。迄今為止,在國際權威刊物上發表SCI論文35篇,作為課題負責人主持國家重點研發計劃“蛋白質機器與生命過程調控”重點專項1項、作為項目負責人主持國家自然科學基金面上項目2項、浙江省自然科學基金杰青項目、浙江大學多學科交叉種子基金和Susan G. Komen for the Cure基金各1項。

教育經歷:

  2002/9 - 2008/1,清華大學,生物學,博士
  1998/9 - 2002/7,廈門大學,生物科學,學士
工作經歷
  2015/1 - 至今,浙江大學,附屬第一醫院,研究員
  2015/1 - 至今,浙江大學,轉化醫學研究院,研究員
2008/7 - 2014/12,美國密歇根大學,放射腫瘤系,博士后
研究領域
  1. mTOR信號通路抑制因子DEPTOR在腫瘤發生中的生理功能;
2. Cullin-RING LigaseCRL E3 泛素連接酶在腫瘤發生中的調節功能;
3. Neddylation信號通路在腫瘤發生中的調節作用。
代表論文

  1.Ma Y*, Cui D*, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ#, Zhao Y#. SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology. 2018 Nov 14. doi:  10.1002/1878-0261.12403. [Epub ahead of print]. (IF=5.704)

 2.Xiong X*, Liu X*, Li H, He H, Sun Y#, Zhao Y#. Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis. Cell Death & Disease. 2018, 9(11):1131. (IF=6.187)

 3.Chen X, Cui D, Bi Y, Shu J, Xiong X, Zhao Y#. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell Cycle. 2018, 17(16):2069-2079. (IF=3.799)

 4.Wang J, Cui D, Gu S, Chen X, Bi Y, Xiong X, Zhao Y#. Autophagy regulates apoptosis by targeting NOXA for degradation. BBA Molecular Cell Research. 2018, 1865(8):1105-1113. (IF=5.282)

 5.Gu S, Cui D, Chen X, Xiong X#, Zhao Y#. PROTACs: An emerging targeting technique for protein degradation in drug discovery. Bioessays. 2018, 40(4):e1700247. (IF=4.597) (Highlight by Advanced Science News)

 6.Zhao Y#, Tan M, Liu X, Xiong X#, Sun Y#. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death & Disease. 2018, 9(2):145. (IF=6.187)

 7.魏文毅#、孫毅#、曹誠、常智杰、陳策實、陳佺、程金科、馮仁田、高大明、胡榮貴、賈立軍、姜天霞、金建平、李匯華、李衛、劉翠華、劉萱、馬蕾娜、繆時英、饒楓、商瑜、宋質銀、萬勇、王恒彬、王平、王占新、吳緬、吳喬、謝旗、謝松波、謝志平、徐平、許執恒、楊波、陽成偉、應美丹、張宏冰、張令強、趙永超、周軍、朱軍、王琳芳、張宏、王琛、邱小波#. 類泛素蛋白及其中文命名. 科學通報. 2018, 63(25):2564-2569.

 8.Chen J, Song W, Du Y, Li Z, Xuan Z, Zhao L, Chen J, Zhao Y, Tuo B, Zheng S, Song P. Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation. Biochemical and Biophysical Research Communications. 2018, 499(3):433-440. (IF=2.559)

 9.Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications. 2017, 8:14002. (IF=12.124)

 10.Song P, Du Y, Song W, Chen H, Xuan Z, Zhao L, Chen J, Chen J, Guo D, Jin C, Zhao Y, Tuo B, Zheng S. KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma. Journal of Cancer. 2017, 8(9):1568-1578. (IF=2.916)

 11.Cui D, Xiong X, Zhao Y#. Cullin-RING ligases in regulation of autophagy. Cell Division. 2016, 11:8. (IF=4.684)

 12.Zhou X, Tan M, Nyati M, Zhao Y, Wang G, Sun Y. Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2016, 113(21):E2935-44. (IF=9.661)

 13.Klionsky D, et al, Zhao Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12(1):1-222. (IF=8.593)

 14.Zhao Y, Morgan M, Sun Y. Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxidants & Redox Signaling. 2014, 21(17):2383-400. (IF=6.337)

 15.Xiong X*, Zhao Y*, Tang F, Wei D, Wang X, Thomas D, Zheng P, Liu Y, Sun Y. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, 3:e02236. (Selected by Faculty of 1000 Cell Biology) (IF=7.725) * co-first author

 16.Li H, Sun G, Zhao Y, Thomas D, Greenson J, Zalupski M, Ben-Josef E, Sun Y. DEPTOR has growth suppression activity against pancreatic cancer cells. Oncotarget. 2014, 5(24):12811-9. (IF=5.168)

 17.Zhou W, Xu J, Zhao Y, Sun Y. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014, 5:6746-55. (IF=5.168)

 18.Li H, Tan M, Jia L, Wei D, Zhao Y, Chen G, Zhao L, Thomas D, Bear D, Sun Y. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation. 2014, 124: 835-46. (IF=12.784)

 19.Zhao Y, Sun Y. The FBW7-KLF2 axis regulates endothelial functions. Cell Research. 2013, 23:741-3. (IF=15.606)

 20.Zhao Y, Sun Y. Cullin-RING Ligases as attractive anti-cancer targets. Current Pharmaceutical Design. 2013, 19:3215-25. (IF=2.611)

 21.Yang D*, Zhao Y*, Liu J, Sun Y, Jia L. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. Autophagy. 2012, 8: 1856-8. (IF=8.593) * co-first author

 22.Zhao Y, Xiong X, Jia L, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012, 3: e386. (IF=5.965)

 23.Zhao Y, Sun Y. CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome? Cell Research. 2012, 22:1224–6. (IF=15.606)

 24.Zhao Y, Sun Y. Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application. Neoplasia. 2012, 14: 360-7. (IF=5.006) (Cover story)

 25.Yang D, Zhao Y, Li A, Wang S, Wang G, Sun Y. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast Cancer Research and Treatment, 2012, 133:189-99. (IF=3.626)

 26.Zhao Y, Xiong X, Sun Y. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell. 2011, 44: 304-16. (IF=14.714) (Research Highlight by Nature Reviews Molecular Cell Biology)

 27.Tan M*, Zhao Y*, Kim S, Liu M, Jia L, Saunders T, Zhu Y, Sun Y. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Developmental Cell. 2011, 21: 1062-76. (IF=9.174) * co-first author

 28.Xiong X, Zhao Y, He HB, Sun Y. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene, 2011, 30: 1798–1811. (IF=7.519)

 29.Tan M, Zhu Y, Kovacev J, Zhao Y, Pan Z, Spitz, D, Sun Y. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells. Free Radical Biology and Medicine, 2010, 49: 976-83. (IF=5.606)

 30.Zhao Y*, Shao W*, Wei H, Qiao J, Lu Y, Sun Y, Mitchelson K, Cheng J, Zhou Y. Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiaeJournal of Proteome Research. 2008, 7: 1315-25. (IF=4.268) * co-first author

 31.Yang Q*, Zhao Y*, Xiong Q, Cheng J. Rapid chip-based capillary electrophoretic mobility shift assay with negative pressure injection for the binding study of transcription factor Abf1 in Saccharomyces cerevisiae. Electrophoresis. 2008, 29: 5003-9. (IF=2.744) * co-first author

 32.Qiao J, Shao W, Wei H, Sun Y, Zhao Y, Xing W, Zhang L, Mitchelson K, Cheng J. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7: 2769-79. (IF=4.268)

 33.Sun Y, Zhang Y, Zeng L, Wu J, Wei L, Ren A, Shao W, Qiao J, Zhao Y, Zhang L, Mitchelson K, Cheng J. Broad profiling of DNA-binding transcription factor activities improves regulatory network construction in adult mouse tissues. Journal of Proteome Research, 2008, 7: 4455-64. (IF=4.268)

 34.Yin H, Zhao Y, Zhang Y, Zhang H, Xu L, Zou Z, Yang W, Cheng J, Zhou Y. Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent. Biotechnology Letters, 2006, 28:99-105. (IF=1.73)

 35.Yin H, Xu H, Zhao Y, Yang W, Cheng J, Zhou Y. Cyclooxygenase- independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays. Biotechnology Letters, 2006, 28:1263-70. (IF=1.73)

 36.Shao W, Wei H, Qiao J, Zhao Y, Sun Y, Zhou Y, Cheng J. Parallel profiling of active transcription factors using an oligonucleotide array-based transcription factor assay (OATFA). Journal of Proteome Research, 2005, 4:1451-6. (IF=4.268)

招聘啟事
  本實驗室長期歡迎優秀的本科生、碩士、博士研究生和博士后加盟,請有意者直接與趙永超老師聯系
聯系方式
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