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呂志民教授招收2019年博士生公告

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    呂志民教授招收2019年博士生,歡迎碩轉博的同學,或者是報考浙江大學且統考成績出來明確肯定上線的考生申請。請有意向的同學將個人簡歷、英語成績證明材料以及其他科研相關材料發送到xieyanyan0723@,郵件主題為:姓名+報考呂志民教授

聯系人:謝老師

聯系電話:0571-86971603

郵箱:xieyanyan0723@

呂志民教授個人簡歷

研究領域:
• 腫瘤代謝

• 腫瘤發生與發展

呂志民教授三個原創性里程碑發現,深刻影響了業界對腫瘤代謝的認識, 同時也對開拓新的腫瘤診治方法提供了創新理論支持:

1.國際上首次闡明生長因子受體促進 Warburg 效應的分子機制
Warburg 效應是近百年前由德國諾貝爾獎獲得者 Warburg 發現的腫瘤代謝 特征; 即腫瘤細胞即使在有氧條件下依然依賴糖酵解供給能量, 而抑制線粒 體能量代謝的現象。Warburg 效應是臨床廣泛使用的 PET 檢查的理論基礎, 但其分子機制一直不明確。呂教授發現, 生長因子受體激活誘導糖酵解酶丙 酮酸激酶 M2(PKM2)轉入細胞核內,結合并激活 beta-catenin (Nature, 2011); 磷酸化組蛋白 H3(Cell,2012) (被 Science Signaling 評選為 2012 年信號轉導 領域的重大突破); 上調糖酵解基因表達并增強葡萄糖攝取和乳酸產生 (Nature Cell Biology, 2012; Molecular Cell, 2012)。另外,首次報導糖酵解 酶磷酸甘油酸激酶(PGK1)轉入線粒體,磷酸化并激活丙酮酸脫氫酶激酶 1(PDHK1),進而抑制線粒體丙酮酸代謝,從而促進 Warburg 效應(Molecular Cell, 2016)。因此, 呂教授揭示該效應是通過細胞核內 PKM2 和線粒體內 PGK1 調節的。
2.國際上首次發現多種重要的代謝酶同時具有蛋白激酶活性 
除磷酸化組蛋白外, PKM2 還磷酸化紡錘體組裝蛋白 Bub3 以調節細胞分裂 中期的染色體分離, 磷酸化肌球蛋白輕鏈 2 以促進胞質分裂(Molecular Cell, 2014)。首次報導肝癌細胞剪接果糖激酶 KHK 基因以表達 KHK-A,其作為 蛋白激酶磷酸化并激活磷酸核糖的焦磷酸合成酶 1(PRPS1)以促進核酸合 成、肝癌形成(Nature Cell Biology, 2016)。另外, KHK-A 磷酸化 p62,激活 Nrf2 促進腫瘤細胞抗氧化反應(Science Advances, 2019)。除了磷酸化 PDHK1 以調節線粒體功能, PGK1 磷酸化 Beclin1 調節自噬(Molecular Cell, 2017)。因此,代謝酶具有蛋白激酶功能的發現為腫瘤診療提供了重要靶點。
3.國際上率先證實多種代謝酶和代謝產物在腫瘤細胞活動調控中具有重要的非代謝功能, 并因此發現多個腫瘤代謝新靶點 
代謝酶和代謝物調節基因表達、有絲分裂、胞質分裂、核酸合成和自噬(Nature Reviews Molecular Cell Biology, 2018)。另外發現(a) 延胡索酸酶調節 DNA 修復(Nature Cell Biology, 2015); (b) 核乙酰輔酶 A 合成酶 2 (ACSS2)在啟 動子區域產生乙酰輔酶 A, 誘導溶酶體生物合成和自噬基因的表達 (Molecular Cell, 2017); (c) α-KGDH 關聯的 Gcn5 作為組蛋白 H3 琥珀酰轉 移酶以調節基因表達(Nature, 2017); (d) 磷酸果糖激酶 1(PFKP)促進 PI3K 激活(Molecular Cell, 2018)。因此, 其科研成果改變了業界對腫瘤代謝的傳統認知。

教育背景:
1998 美國紐約市立大學 分子、細胞及發育生物學專業 博士
1986 泰山醫學院 臨床醫學專業 學士

研究工作經歷:
2019—至今  浙江大學轉化醫學研究院 院長
2015—2018 美國德克薩斯大學MD安德森癌癥中心Ruby E. Rutherford杰出教授
2013—2018 德克薩斯大學安德森癌癥中心神經腫瘤學 教授(終身教職)
2009—2013 德克薩斯大學安德森癌癥中心神經腫瘤學 副教授(終身教職)
2003—2009 德克薩斯大學安德森癌癥中心神經腫瘤學 助理教授
1999—2003  SALK生物學研究所分子細胞腫瘤學 研究助理/博士后
1993—1999 紐約市立大學研究生院分子細胞腫瘤學 研究助理
1986—1993 青島醫院腫瘤內科 醫生

榮譽及獎項:
2019 浙江大學王寬誠杰出講席教授
2018 美國國家藝術與科學院院士提名
2017 美國科學促進會(American Association for the Advancement of Science )會士
2016 美國德克薩斯大學MD安德森癌癥中心Dallas/Fort Worth傳奇人物基礎研究成就獎
2015 美國德克薩斯大學科學技術獲得和保留(STARs)獎
2013 美國德克薩斯大學MD安德森癌癥中心Potu N. Rao基礎科學卓越獎
2012 美國James S. McDonnell基金會學者獎
2011 美國德克薩斯大學MD安德森癌癥中心Faculty學者獎
2009 美國癌癥協會研究學者獎
2008 美國Peter Steck青年研究者獎
2005 中國科學院王寬誠基金會獎
2000 美國加州乳腺癌研究計劃博士后獎學金
1999 美國Salk先鋒基金獎學金
1997 美國紐約城市大學亨特學院生命科學 Beatrice Goldstein Konheim 研究生獎學金

代表性論著:
1. Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Molecular Cell, 2002, 9(5):945-56, (Highlighted in: Nat Rev Mol Cell Biol 2002;3:473; Nature-Signaling Update/the signaling gateway, 2002; and Faculty of 1000 Biology)..
2. Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell, 2003, 4(6):499-515 (Highlighted in: Nat Rev Cancer 2004; 4:90-91; Nature Signaling & Update/The signaling gateway 2004, and Faculty of 1000 Biology).
3. Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.  (Highlighted in Faculty of 1000 Biology; Selected as the feature article by Mol Cell and received MDACC Nycomed GmbH Outstanding Research Publication Award in 2007). Molecular Cell, 2007, 5(2):219-32. PMCID: PMC1829326.
4. Lu Z, Hunter T. Degradation of activated protein kinases by ubiquitination. Annual Review Biochemistry, 2009, 78:435-75. PMCID: PMC2776765.
5. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, Zhou X, Aldape K, Cobb M, Xie K, He J, and Lu Z. FAK phosphorylation by ERK primes Ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Molecular Cell, 2009, 35(1):11-25 (Highlighted in Mol Cell and Faculty of 1000 Biology). PMCID: PMC2715139.
6. Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Molecular Cell, 2009 36(4):547-59 (Selected as the feature article by Mol Cell and highlighted in Cell and M.D. Anderson News Release). PMCID: PMC2784926.
7. Yang W, Xia X, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature. 2011, 480(7375):118-22, PMID: 22056988 (2011 Outstanding Research Publication Award at MD Anderson; Highlighted in Cell Leading Edge, Nature SciBX, Science Signaling, Cancer Research, Cell Research, Chinese journal of Cancer, Future Oncology, and Faculty of 1000 Biology, and M.D. Anderson News Release).
8. Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell, 2012; 150 (4): 685-696 (Listed in 2012: Signaling Breakthroughs of the Year, Science Signaling; Highlighted in Cell Leading Edge, Nature Reviews Cancer, Cancer Discovery, Cell Cycle, Faculty of 1000 Biology, and M.D. Anderson News Release).
9. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You M, Koh M, Cote G, Aldape K, Li Y, Verma I, Chiao P, and Lu Z. EGFR-induced and PKC monoubiquitylation-dependent NF-B activation upregulates PKM2 expression and promotes turmorigenesis. Molecular Cell, 2012; 48(5):771-84 PMID:23123196 (Highlighted in Cancer Discovery and M.D. Anderson News Release)
10. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Fang G, Lyssiotis C, Aldape K, Cantley L, and Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology, 2012;14(12):1295-304, PMID:23178880 (Highlighted in Nature Review Cancer 13, 5, 2013; Nature Chemical Biology; Cell Cycle and M.D. Anderson News Release)
11. Jiang Y, Li X, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, and Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Molecular Cell, 2014. 53(1):75-87. PMID: 24316223 (Highlighted in Cancer Discovery and M.D. Anderson News Release).
12. Jiang Y, Wang Y, Wang T, Hawke D, Zheng Y, Li X, Majumder S, Bi E, Liu D, Huang S, and Lu Z. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells. Nature Communications. 2014. (Highlighted in M.D. Anderson News Release).
13. Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li G, Yang J, Li X, Lu Z, and Liu D. ATF5 connects the pericentriolar material to the proximal end of the mother centriole in the centrosome. Cell, 2015. 162(3):580-92. PMID: 26213385.
14. Jiang Y, Shen J, Wang Y, Qian X, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin S, and Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biology, 2015.7(9):1158-68. PMID: 26237645. (highlighted in Nature Cell Biology, Cancer Discovery, Science Signaling, and an MD Anderson news release).
15. Zheng Y, Li X, Qian X, Wang Y, Lee J, Xia Y, Hawke D, Zhang G, Lu J, and Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nature Cell Biology, 2015. 17(10):1348-55. PMID: 26280537 (highlighted in Cancer Discovery, Science Signaling, and an MD Anderson news release).
16. Ji H, Lee J, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z. EGFR phosphorylates FAM129B to promote Ras activation. PNAS. 2016. 113(3):644-9.  PMID:26721396.
17. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, and Lu Z. Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis. Molecular Cell. 2016. 61(5):705-719. PMID:26942675. (highlighted in MD Anderson news release).
18. Li X, Qian X, Peng L, Jiang Y, Hawke D, Zheng Y, Xia Y, Lee J, Cote G, Wang H, Wang L, Qian C, and Lu Z. Splicing Switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinomagenesis. Nature Cell Biology, 2016. 18(5):561-71. PMID:2708854. (Highlighted in Cancer Discovery, Science Signaling, and an MD Anderson news release).
19. Liang J, Cao R, Xia Y, Zheng Y, Li X, Wang L, Yang W and Lu Z. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 2016, 7:12431. PMID: 27485204
20. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Molecular Cell. 2017 Mar 2;65(5):917-931.PMID: 28238651 (Highlighted in Autophagy and an MD Anderson news release).
21. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Ji H, Li J, and Lu Z. EGF-induced histone H3 polyubiquitylation and nucleosome disassembly promote gene expression and tumorigenesis. The Journal of Experimental Medicine. 2017. 214 (6), 1843-1855. PMID:28507061.
22. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, Li W, Lyu J, Rao G, Zhang X, Qian C, Rozen S, Jiang T, Lu Z. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell. 2017;66(5):684-697. PMID:28552616. (Highlighted in Nature Reviews Molecular Cell Biology and an MD Anderson news release).
23. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, Groot J, Tao Jiang T, Lu Z. Stabilization of Phosphofructokinase 1 Platelet Isoform by AKT Promotes Tumorigenesis. Nature Communications. 2017; 16;8(1):949. doi: 10.1038/s41467-017-00906-9. PMID: 29038421
24. Qian X, Li X, Tan L, Lee JH, Xia X, Cai Q, Zheng Y, Wang H, Lorenzi P, Lu Z. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery, 2017. PMID: 29074724.
25. Wang Y,Guo Y, Liu K, Liu R, Tan L, Yang P, Lee J, Du L, Xia Y, Li X, Hawke D, Zheng Y, He J, Xing D, Tao Y, Lu Z. KAT2A Coupled with the -KGDH Complex Acts as a Histone H3 Succinyltransferase. Nature, 2017. PMID: 29211711 (Highlighted in Cancer Discovery and an MD Anderson news release). 
26. Lu Z and Hunter T. Metabolic Kinases Moonlighting as Protein Kinases. Trends in Biochemical Sciences. 2018. (4):301-310. PMID: 29463470.
27. Lee JH, Liu R, Li J., Wang YG, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng y, Chen Q, Lorenzi PL, Mills GB, Jiang T, and Lu Z. EGFR-phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Molecular Cell, 2018 Apr 19;70(2):197-210. PMID: 29677490
28. Li X, Wang Y., and Lu Z. Metabolic regulation of epigenetics and gene expression. Nature Reviews Molecular Cell Biology. 2018.
29.Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.  Molecular Cell, 2018. 72 (4): 650-660. PMID: 30392930.
30.Xu D, Li X, Lv G, Lv H, Lee J, Qian X, Wang Z, Xia Y, Du L, Cai Q, Zeng Y, Wang H, and Lu Z. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances, 2019.